Biomarkers are important parameters that are reliable, applicable, reproducible and typically low-cost. They play a significant role in human health, particularly mechanistic biomarkers, which are of the utmost importance for preventing toxic effects and diseases. They can reflect the diagnosis, prognosis, recurrence and progression of diseases. Furthermore, they can indicate the level of human...
Two important mechanisms used by antibody to kill targeted cells are Antibody-Dependent Cell-Mediated Cytotoxicity (ADCC), and Complement Dependent Cytotoxicity (CDC). Reliable and high quality ADCC & CDC assays have assumed greater significance with the growing importance in medicine of bio-engineering antibodies and their role in combating cancers. By implementing strict QC standards,...
The primary purpose of food was initially to provide essential nutrition for human beings to sustain their daily activities. However, due to dietary habits and lifestyle changes, food has now emerged as a trigger for lifestyle-related diseases, such as obesity, high blood pressure, and diabetes. For prevention of the lifestyle-related diseases, it is necessary to improve the eating habits,...
Immunogenicity is a major problem with protein-based therapeutics due to circulating anti-drug antibody (ADA) production. ADA may lead to many clinical problems including allergic reactions, altered pharmacokinetic, reduced efficacy, etc. Thus, perform an immunogenicity testing to evaluate the ADA level induced by therapeutic protein drug is a necessary step in both clinical studies and post...
The first step in vaccine development is antigen discovery, a process that determines whether the vaccine can successfully stimulate a protective immune response. Pathogen-associated molecules can induce a specific immune response in the host, and the core goal of antigen discovery is to identify these molecules in order to prevent infection.
Antigen discovery typically begins with the...
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